Sacubitril 49 mg & Valsartan 51 mg Tablets
Active Ingredients: Each tablet contains 49 mg of Sacubitril and 51 mg of Valsartan.
Purpose:
- Heart Failure Treatment: This combination medication is primarily used to treat chronic heart failure in adults, helping to improve heart function and reduce the risk of hospitalization and cardiovascular death.
Uses:
Sacubitril/Valsartan is effective in managing heart failure by:
- Reducing Hospitalization: Helps lower the risk of hospitalization due to heart failure.
- Decreasing Mortality: Aims to reduce the risk of cardiovascular death in patients with chronic heart failure.
- Improving Symptoms: Enhances overall heart function and alleviates symptoms associated with heart failure.
Mechanism of Action:
- Sacubitril: An neprilysin inhibitor that increases levels of natriuretic peptides, leading to vasodilation and diuresis, which helps reduce blood pressure and fluid overload.
- Valsartan: An angiotensin II receptor blocker (ARB) that helps relax blood vessels, lowering blood pressure and reducing the workload on the heart.
Dosage:
- Recommended Use: The typical starting dose is 49 mg/51 mg taken orally twice daily. The dosage may be adjusted based on the patient's response and tolerance, with a maximum recommended dose of 97 mg/103 mg.
Important Considerations:
- Side Effects: Common side effects may include:
- Hypotension (low blood pressure)
- Hyperkalemia (high potassium levels)
- Renal impairment
- Dizziness
- Contraindications: Not suitable for patients with:
- A history of angioedema related to previous ACE inhibitor or ARB therapy
- Severe renal impairment
- Pregnancy or breastfeeding
Warnings:
- Caution is advised in patients with renal impairment or those taking other medications that may affect kidney function.
Storage:
- Store in a cool, dry place away from direct sunlight and out of reach of children.
Sacubitril/Valsartan is a vital option for managing chronic heart failure, providing significant benefits in reducing hospitalization and improving quality of life. Always consult with a healthcare professional for personalized advice and treatment plans.