Dapagliflozin 10 mg & Metformin HCl (ER) 1000 mg Tablets

Combination Medication: This tablet combines two active ingredients:

• Dapagliflozin 10 mg: A sodium-glucose cotransporter 2 (SGLT2) inhibitor.
• Metformin Hydrochloride (HCl) 1000 mg: A biguanide medication.

Purpose:

• Antidiabetic: Used to improve blood sugar control in adults with type 2 diabetes mellitus.

Uses:

1. Type 2 Diabetes Management:
   • Helps lower blood glucose levels by:
     • Dapagliflozin: Increasing glucose excretion in the urine.
     • Metformin: Reducing glucose production in the liver and improving insulin sensitivity.
2. Glycemic Control:
   • Used in conjunction with diet and exercise to improve overall glycemic control.

Mechanism of Action:

• Dapagliflozin: Blocks the SGLT2 protein in the kidneys, preventing glucose reabsorption and increasing glucose excretion in urine.
• Metformin: Reduces glucose production in the liver, decreases intestinal absorption of glucose, and improves insulin sensitivity.

Dosage:

• Recommended Use: Dosage is determined by a healthcare provider and is based on individual needs and prior treatment. Typically, it is taken orally once or twice daily with meals to reduce gastrointestinal side effects.

Important Considerations:

• Side Effects: Common side effects may include:
  • Dapagliflozin:
    • Urinary tract infections
    • Genital mycotic infections
    • Increased urination
  • Metformin:
    • Nausea
    • Diarrhea
    • Abdominal pain
• Contraindications: Not suitable for patients with:
  • Severe renal impairment
  • Metabolic acidosis
  • Hypersensitivity to any of the ingredients
• Warnings:
  • Risk of ketoacidosis
  • Dehydration and hypotension

Storage:

• Store in a cool, dry place away from direct sunlight and out of reach of children.

This combination medication offers a comprehensive approach to managing type 2 diabetes by addressing multiple aspects of glucose regulation. Always consult with a healthcare professional for personalized advice and treatment plans.

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